研究業績
Publications

2023年

欧文原著

• Gamirova R, Shagimardanova E, Sato T, Kannon T, Gamirova R, Tajima A. 
  Identification of potential disease-associated variants in idiopathic generalized epilepsy using targeted sequencing.
  J Hum Genet in press, 2023.
• Hazawa M, Ikliptikawati DK, Iwashima Y, Lin DC, Jiang Y, Qiu Y, Makiyama K, Matsumoto K, Kobayashi A, Nishide G, Keesiang L, Yoshino H, Minamoto T, Suzuki T, Kobayashi I, Meguro-Horike M, Jiang YY, Nishiuchi T, Konno H, Koeffler HP, Hosomichi K, Tajima A, Horike SI, Wong RW. 
  Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells.
  Cell Chem Biol in press, 2023.
• Yamagami K, Tada H, Sato T, Nomura A, Sakata K, Usui S, Kawashiri MA, Tajima A, Takamura M. 
  Genetic characteristics contributing to lipoprotein(a) levels in the Japanese population.
  J Coron Artery Dis 29(4):104-108, 2023.
• Hara A, Tsujiguchi H, Suzuki K, Nakamura M, Okada M, Zhao J, Takazawa C, Suzuki F, Kasahara T, Shimizu Y, Tsuboi H, Kannon T, Tajima A, Takamura T, Nakamura H. 
  Distinct associations between dietary omega-3 and omega-6 fatty acids intake with chronic kidney disease in adults with and without diabetes: a cross-sectional study.
  Nutrition 115:112156, 2023.
• Okuwaki S, Hosomichi K, Tajima A, Yamaguchi T. 
  An observational study on changes in the oral and gut microbiota through professional mechanical tooth cleaning, including tooth-brushing instructions in patients with multi-bracket appliances.
  Appl Sci 13(19):10843, 2023.
• Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A. 
  Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation.
  Cell Death Dis 14(9):642, 2023.
• Hattori T, Cherepanov SM, Sakaga R, Roboon J, Nguyen DT, Ishii H, Takarada-Iemata M, Nishiuchi T, Kannon T, Hosomichi K, Tajima A, Yamamoto Y, Okamoto H, Sugawara A, Higashida H, Hori O. 
  Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory.
  EMBO J 42(15):e111247, 2023.
• Toyama T, Shimizu M, Yamaguchi T, Kurita H, Morita T, Oshima M, Kitajima S, Hara A, Sakai N, Hashiba A, Takayama T, Tajima A, Furuichi K, Wada T, Iwata Y. 
  A comprehensive risk factor analysis using association rules in people with diabetic kidney disease.
  Sci Rep 13(1):11690, 2023.
• Nayema Z, Sato T, Kannon T, Tsujiguchi H, Hosomichi K, Nakamura H, Tajima A. 
  Genetic factors associated with serum amylase in a Japanese population: Combined analysis of copy-number and single-nucleotide variants.
  J Hum Genet 68(5):313-319, 2023.
• Cui S, Hayashi K, Kobayashi I, Hosomichi K, Nomura A, Teramoto R, Usuda K, Okada H, Deng Y, Kobayashi-Sun J, Nishikawa T, Furusho H, Saito T, Hirase H, Ohta K, Fujimoto M, Horita Y, Kusayama T, Tsuda T, Tada H, Kato T, Usui S, Sakata K, Fujino N, Tajima A, Yamagishi M, Takamura M. 
  The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1variants.
  J Mol Cell Cardiol 177:50-61, 2023.
• Yamamoto R, Takeshita Y, Tsujiguchi H, Kannon T, Sato T, Hosomichi K, Suzuki K, Kita Y, Tanaka T, Goto H, Nakano Y, Yamashita T, Kaneko S, Tajima A, Nakamura H, Takamura T. 
  Nutrigenetic interaction between apolipoprotein C3 polymorphism and fat intake in people with non-alcoholic fatty liver disease.
  Curr Dev Nutr 7(4):100051, 2023.
• Ogawa A, Tsujiguchi H, Nakamura M, Hayashi K, Hara A, Suzuki K, Miyagi S, Kannon T, Takazawa C, Zhao J, Kambayashi Y, Shimizu Y, Shibata A, Konoshita T, Suzuki F, Tsuboi H, Tajima A, Nakamura H. 
  Higher intake of vegetable protein and lower intake of animal fats reduce the incidence of diabetes in non-drinking males: A prospective epidemiological analysis of the Shika study.
  Nutrients 15(4):1040, 2023.
• Fukushima S, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Yanagisawa T, Oku F, Sato K, Nakamura M, Hayashi K, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H. 
  Relationships among depressive symptoms, body weight, and chronic pain: A cross-sectional analysis of the Shika study.
  Behav Sci 13(2):86, 2023.
• Nakai S, Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kasahara T, Nakamura M, Takazawa C, Kannon T, Tajima A, Tsuboi H, Ogino N, Konoshita T, Takamura T, Nakamura H. 
  Association between bone mineral density and oral frailty on renal function: Findings from the Shika study.
  Healthcare 11(3):314, 2023.

欧文報告

• Mizumaki H, Tran DC, Hosokawa K, Hosomichi K, Zaimoku Y, Takamatsu H, Yamazaki H, Ishiyama K, Yamazaki R, Fujiwara H, Tajima A, Nakao S. 
  Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells.
  Blood Cancer J 13(1):165, 2023.
• Imi T, Mizumaki H, Hosomichi K, Nannya Y, Zaimoku Y, Yoroidaka T, Katagiri T, Ishiyama K, Yamazaki H, OgawaR, Kuroiwa M, Tajima A, Ogawa S, Nakao S. 
  Familial immune-mediated aplastic anaemia in six different families.
  eJHaem 4(3):714-718, 2023.

2022年

欧文原著

• Suzuki K, Tsujiguchi H, Hara A, Miyagi S, Nguyen TTT, Kambayashi Y, Shimizu Y, Suzuki F, Takazawa C, Nakamura M, Tsuboi H, Kannon T, Tajima A, Nakamura H. 
  Bone strength of the calcaneus is associated with dietary calcium intake in older Japanese men, but not women.
  Nutrients 14(24):5225, 2022
• Sato K, Suzuki F, Tsujiguchi H, Hara A, Kannon T, Miyagi S, Suzuki K, Nakamura M, Takazawa C, Shibata A, Tsuboi H, Shimizu Y, Nguyen TTT, Konoshita T, Ono Y, Hayashi K, Tajima A, Nakamura H. 
  Relationship between vitamin intake and resilience based on sex in middle-aged and older Japanese adults: Results of the Shika study.
  Nutrients 14(23):5042, 2022
• Park H, Hosomichi K, Kim Y-I, Hikita Y, Tajima A, Yamaguchi T.  
  Comprehensive genetic exploration of fused teeth by whole exome sequencing.
  Appl Sci 12(23):11899, 2022
• Yanagisawa T, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Oku F, Sato K, Nakamura M, Hayashi K, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H. 
  Hypertension and low body weight are associated with depressive symptoms only in females: Findings from the Shika study.
  Behav Sci 12(11):413, 2022
• Tsuboi H, Matsunaga M, Tsujiguchi H, Kannon T, Hosomichi K, Sato T, Tajima A, Yoshida N, Hara A, Nakamura H. 
  Elevated ratio of serum anandamide to arachidonic acid intake in community-dwelling women with high depressive symptoms.
  Neuro Endocrinol Lett 43(3):145-153.
• Roboon J, Hattori T, Nguyen DT, Ishii H, Takarada-Iemata M, Kannon T, Hosomichi K, Maejima T, Saito K, Shinmyo Y, Mieda M, Tajima A, Kawasaki H, Hori O. 
  Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes.
  Front Cell Neurosci 16:877131, 2022.
• Sato K, Tsujiguchi H, Suzuki F, Hara A, Kannon T, Muto G, Hori D, Miyagi S, Suzuki K, Nakamura M, Takazawa C, Kasahara T, Tsuboi H, Matsui M, Tajima A, Nakamura H. 
  Relationship between social capital and depressive symptoms: Differences according to resilience and gender in the Shika study.
  J Affect Disord Rep 10:100421, 2022.
• Yoshida K, Kawashima H, Kannon T, Tajima A, Ohno N, Terada K, Takamatsu A, Adachi H, Ohno M, Miyati T, Ishikawa S, Ikeda H, Gabata T. 
  Prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer using radiomics of pretreatment dynamic contrast-enhanced MRI.
  Magn Reson Imaging 92:19-25, 2022.
• Park H, Hosomichi K, Kim Y-I, Tajima A, Yamaguchi T. 
  Exploring the genetic basis of dens evaginatus using whole exome sequencing.
  Appl Sci 12(18):8962, 2022.
• Pham LT, Peng H, Ueno M, Kohno S, Kasada A, Hosomichi K, Sato T, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Xiao B, Worley PF, Takahashi C, Tajima A, Hirao A. 
  RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia.
  Biochem Biophys Res Commun 621:74-79, 2022.
• Mori Y, Miyake M, Hosoda Y, Miki A, Takahashi A, Muraoka Y, Miyata M, Sato T, Tamura H, Ooto S, Yamada R, Yamashiro K, Nakamura M, Tajima A, Nagasaki M, Honda S, Tsujikawa A. 
  Genome-wide survival analysis for macular neovascularization development in central serous chorioretinopathy revealed shared genetic susceptibility with polypoidal choroidal vasculopathy.
  Ophthalmology 129(9):1034-1042, 2022.
• Kress S, Hara A, Wigmann C, Sato T, Suzuki K, Pham KO, Zhao Q, Areal A, Tajima A, Schwender H, Nakamura H, Schikowski T. 
  The role of polygenic susceptibility on air pollution-associated asthma between German and Japanese elderly women.
  Int J Environ Res Public Health 19(16):9869, 2022.
• Suzuki C, Nishiyama A, Arai S, Tange S, Tajima A, Tanimoto A, Fukuda K, Takumi Y, Kotani H, Takeuchi S, Yanagimura N, Ohtsubo K, Yamamoto N, Omori K, Yano S. 
  Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells.
  Cancer Sci 113(7):2323-2335, 2022.
• Oku F, Hara A, Tsujiguchi H, Suzuki K, Pham KO, Suzuki F, Miyagi S, Nakamura M, Takazawa C, Sato K, Yanagisawa T, Kannon T, Tajima A, Nakamura H. 
  Association between dietary fat intake and hyperuricemia in men with chronic kidney disease.
  Nutrients 14(13):2637, 2022.
• Asai A, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Nakamura M, Shimizu Y, Nguyen TTT, Pham KO, Kasahara T, Nakai S, Hayashi K, Shibata A, Amatsu T, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H. 
  Relationship between fatty acid intake and chronic neck/shoulder/upper limb pain without elevated CRP in a Japanese population: a cross-sectional analysis of the Shika study.
  J Nutr Sci 11:e38, 2022.
• Suzuki K, Tsujiguchi H, Hara A, Pham OK, Miyagi S, Nguyen TTT, Nakamura H, Suzuki F, Kasahara T, Shimizu Y, Yamada Y, Kambayashi Y, Tsuboi H, Sato T, Kannon T, Hosomichi K, Tajima A, Takamura T, Nakamura H. 
  Association between serum 25-hydroxyvitamin D concentrations, CDX2 polymorphism in promoter region of vitamin D receptor gene, and chronic pain in rural Japanese residents.
  J Pain Res 15:1475-1485, 2022.
• Pham KO, Hara A, Tsujiguchi H, Suzuki K, Suzuki F, Miyagi S, Kannon T, Sato T, Hosomichi K, Tsuboi H, Nguyen TTT, Shimizu Y, Kambayashi Y, Nakamura M, Takazawa C, Nakamura H, Hamagishi T, Shibata A, Konoshita T, Tajima A, Nakamura H. 
  Association between vitamin intake and chronic kidney disease according to a variant located upstream of the PTGS1 gene: A cross-sectional analysis of Shika study.
  Nutrients 14(10):2082, 2022.
• Hara A, Nguyen PM, Tsujiguchi H, Nakamura M, Yamada Y, Suzuki K, Suzuki F, Kasahara T, Pham KO, Nakamura H, Kambayashi Y, Shimizu Y, Nguyen TTT, Miyagi S, Kannon T, Sato T, Hosomichi K, Tajima A, Nakamura H. 
  Effect of β3-adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross-sectional study.
  Obes Sci Pract 8(2):199-207, 2022.
• Takahashi M, Hosomichi K, Nakaoka H, Sakata H, Uesato N, Murakami K, Kano M, Toyozumi T, Matsumoto Y, Isozaki T, Sekino N, Otsuka R, Inoue I, Matsubara H. 
  Biased expression of mutant alleles in cancer-related genes in esophageal squamous cell carcinoma.
  Esophagus 19(2):294-302, 2022.
• Katano K, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Pham KO, Asai A, Kasahara T, Nakamura M, Takazawa C, Hayashi K, Hamagishi T, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Kobayashi T, Nakamura H. 
  Association of immunoglobulin E levels with smoking and trace element intake: A cross-sectional analysis of the Shika study.
  Glob J Nutri Food Sci 3(5):GJNFS.MS.ID.000571, 2022
• Shinmyo Y, Saito K, Hamabe-Horiike T, Kameya N, Ando A, Kawasaki K, Duong TAD, Sakashita M, Roboon J, Hattori T, Kannon T, Hosomichi K, Slezak M, Holt MG, Tajima A, Hori O, Kawasaki H. 
  Localized astrogenesis regulates gyrification of the cerebral cortex.
  Sci Adv 8(10):eabi5209, 2022.
• Sakaue S, Hosomichi K, Hirata J, Nakaoka H, Yamazaki K, Yawata M, Yawata N, Naito T, Umeno J, Kawaguchi T, Matsui T, Motoya S, Suzuki Y, Inoko H, Tajima A, Morisaki T, Matsuda K, Kamatani Y, Yamamoto K, Inoue I, Okada Y. 
  Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method.
  Cell Genom 2(3):100101, 2022.
• Koga M, Senkoji T, Kubota M, Ishizaka A, Mizutani T, Sedohara A, Ikeuchi K, Kikuchi T, Adachi E, Saito M, Koibuchi T, Hosomichi K, Ohashi J, Kawana-Tachikawa A, Matano T, Tsutsumi T, Yotsuyanagi H. 
  Predictors associated with a better response to the Japanese aluminum-free hepatitis A vaccine, Aimmugen®, for people living with HIV.
  Hepatol Res 52(3):227-234, 2022.
• Kasahara T, Tsujiguchi H, Takeshita Y, Hara A, Suzuki K, Narukawa N, Hayashi K, Miyagi M, Asai A, Yamada Y, Nakamura H, Suzuki F, Pham KO, Hamagishi T, Nakamura M, Shibata A, Shimizu Y, Nguyen TTT, Miyagi S, Kambayashi Y, Kannon T, Tajima A, Tsuboi H, Konoshita T, Takamura T, Nakamura H. 
  A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values.
  BMC Endocr Disord 22(1):40, 2022.
• Amatsu T, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Pham KO, Suzuki F, Kasahara T, Nakamura M, Hayashi K, Shibata A, Ogino N, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H. 
  Relationship between alcohol intake and chronic pain with depressive symptoms: A cross-sectional analysis of the Shika study.
  Int J Environ Res Public Health 19(4):2024, 2022.
• Ahammad RU, Nishioka T, Yoshimoto J, Kannon T, Amano M, Funahashi Y, Tsuboi D, Faruk MO, Yamahashi Y, Yamada K, Nagai T, Kaibuchi K. 
  KANPHOS: A Database of Kinase-Associated Neural Protein Phosphorylation in the Brain.
  Cells 11(1):47, 2022.
• Yoshiji S, Horikawa Y, Kubota S, Enya M, Iwasaki Y, Keidai Y, Aizawa-Abe M, Iwasaki K, Honjo S, Hosomichi K, Yabe D, Hamasaki A. 
  First Japanese family With PDX1-MODY (MODY4): A novel PDX1 frameshift mutation, clinical characteristics, and implications.
  J Endocr Soc 6(1):bvab159, 2022.
• Nishijima H, Matsumoto M, Morimoto J, Hosomichi K, Akiyama N, Akiyama T, Oya T, Tsuneyama K, Yoshida H, Matsumoto M. 
  Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens.
  J Immunol 208(2):303-320, 2022.
• Jinam TA, Hosomichi K, Nakaoka H, Phipps ME, Saitou N, Inoue I. 
  Allelic and haplotypic HLA diversity in indigenous Malaysian populations explored using next generation sequencing.
  Hum Immunol 83(1):17-26, 2022.

欧文報告

• Yamamura M, Sato Y, Takahashi K, Nguyen Canh H, Li Z, Hosomichi K, Tajima A, Terada T, Nakanuma Y, Harada K. 
  A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins.
  Hum Pathol Rep 29:300660, 2022.
• Sakai K, Ishida C, Hayashi K, Tsuji N, Kannon T, Hosomichi K, Takei N, Kakita A, Tajima A, Yamada M. 
  Familial idiopathic basal ganglia calcification with a heterozygous missense variant (c.902C>T/p.P307L) in SLC20A2 showing widespread cerebrovascular lesions.
  Neuropathology 42(2):126-133, 2022.
• Nomura N, Iizuka K, Goshima E, Hosomichi K, Tajima A, Kubota S, Liu Y, Takao K, Kato T, Mizuno M, Hirota T, Suwa T, Horikawa Y, Yabe D. 
  Glucokinase-maturity onset diabetes mellitus in the young suggested by factory-calibrated glucose monitoring data: a case report.
  Endocr J 69(4):473-477, 2022.

2021年

欧文原著

• Koba H, Kimura H, Yoneda T, Ogawa N, Tanimura K, Tambo Y, Sone T, Hosomichi K, Tajima A, Kasahara K. 
  NOTCH alteration in EGFR-mutated lung adenocarcinoma leads to histological small-cell carcinoma transformation under EGFR-TKI treatment.
  Transl Lung Cancer Res 10(11):4161-4173, 2021.
• Robbeets M, Bouckaert R, Conte M, Savelyev A, Li T, An DI, Shinoda KI, Cui Y, Kawashima T, Kim G, Uchiyama J, Dolinska J, Oskolskaya S, Yamano KY, Seguchi N, Tomita H, Takamiya H, Kanzawa-Kiriyama H, Oota H, Ishida H, Kimura R, Sato T, Kim JH, Deng B, Bjorn R, Rhee S, Ahn KD, Gruntov I, Mazo O, Bentley JR, Fernandes R, Roberts P, Bausch IR, Gilaizeau L, Yoneda M, Kugai M, Bianco RA, Zhang F, Himmel M, Hudson MJ, Ning C. 
  Triangulation supports agricultural spread of the Transeurasian languages.
  Nature 599(7886):616-621, 2021
  [NEWS AND VIEWS] Nature 599(7886):557-558, 2021.
• Hayashi K, Noguchi-Shinohara M, Sato T, Hosomichi K, Kannon T, Abe C, Domoto C, Yuki-Nozaki S, Mori A, Horimoto M, Yokogawa M, Sakai K, Iwasa K, Komai K, Ishimiya M, Nakamura H, Ishida N, Suga Y, Ishizaki J, Ishigami A, Tajima A, Yamada M. 
  Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study.
  PLoS One 16(11):e0259663, 2021.
• Osawa Y, Aoyama K, Hosomichi K, Uchibori M, Tajima A, Kimura M, Ota Y. 
  Somatic mutations in oral squamous cell carcinomas in 98 Japanese patients and their clinical implications.
  Cancer Treat Res Commun 29:100456, 2021.
• Nomura A, Sato T, Tada H, Kannon T, Hosomichi K, Tsujiguchi H, Nakamura H, Takamura M, Tajima A, Kawashiri MA. 
  Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia.
  J Hum Genet 66(11):1079-1087, 2021.
• Sato T, Adachi N, Kimura R, Hosomichi K, Yoneda M, Oota H, Tajima A, Toyoda A, Kanzawa-Kiriyama H, Matsumae H, Koganebuchi K, Shimizu KK, Shinoda KI, Hanihara T, Weber A, Kato H, Ishida H. 
  Whole genome sequencing of a 900-year-old human skeleton supports two past migration events from the Russian Far East to northern Japan.
  Genome Biol Evol 13(9):evab192, 2021.
• Aamer W, Hassan HY, Nakaoka H, Hosomichi K, Jaeger M, Tahir H, Abdelraheem MH, Netea MG, Inoue I. 
  Analysis of HLA gene polymorphisms in East Africans reveals evidence of gene flow in two Semitic populations from Sudan.
  Eur J Hum Genet 29(8):1259-1271, 2021.
• Matsumae H, Ranacher P, Savage PE, Blasi DE, Currie TE, Koganebuchi K, Nishida N, Sato T, Tanabe H, Tajima A, Brown S, Stoneking M, Shimizu KK, Oota H, Bickel B. 
  Exploring correlations in genetic and cultural variation across language families in northeast Asia.
  Sci Adv 7(34):eabd9223, 2021.
  [FOCUS] Sci Adv 7(41):eabm2472, 2021.
• Yamada Y, Nakamura H, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Sato T, Hosomichi K, Nguyen TTT, Kambayashi Y, Shimizu Y, Pham KO, Suzuki K, Suzuki F, Kasahara T, Tsuboi H, Tajima A, Nakamura H. 
  Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population.
  PLoS One 16(8):e0255444, 2021.
• Saenz SS, Arias B, Hosomichi K, Romero VI. 
  The limits of clinical findings in similar phenotypes, from Carpenter to ATRX syndrome using a whole exome sequencing approach: a case review.
  Hum Genomics 15(1):49, 2021.
• Hirayasu K, Sun J, Hasegawa G, Hashikawa Y, Hosomichi K, Tajima A, Tokunaga K, Ohashi J, Hanayama R. 
  Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.
  J Hum Genet 66(7):739-748, 2021.
• Matsukawa H, Iida N, Kitamura K, Terashima T, Seishima J, Makino I, Kannon T, Hosomichi K, Yamashita T, Sakai Y, Honda M, Yamashita T, Mizukoshi E, Kaneko S. 
  Dysbiotic gut microbiota in pancreatic cancer patients form correlation networks with the oral microbiota and prognostic factors.
  Am J Cancer Res 11(6):3163-3175, 2021.
• Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Nguyen MAT, Tran DC, Elbadry MIY, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S. 
  A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.
  Haematologica 106(6):1581-1590, 2021.
• Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, Saito S, Mori K, Hori O. 
  The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.
  Sci Rep 11(1):13086, 2021.
• Miyagi S, Takamura T, Nguyen TTT, Tsujiguchi H, Hara A, Nakamura H, Suzuki K, Tajima A, Kannon T, Toyama T, Kambayashi Y, Nakamura H. 
  Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men.
  J Diabetes Investig 12(5):869-876, 2021.
• Yamamura Y, Furuichi K, Murakawa Y, Hirabayashi S, Yoshihara M, Sako K, Kitajima S, Toyama T, Iwata Y, Sakai N, Hosomichi K, Murphy PM, Tajima A, Okita K, Osafune K, Kaneko S, Wada T. 
  Identification of candidate PAX2-regulated genes implicated in human kidney development.
  Sci Rep 11(1):9123, 2021.
• Koba H, Kimura H, Yoneda T, Sone T, Ohkura N, Hara J, Hosomichi K, Tajima A, Kasahara K. 
  Molecular features of tumor-derived genetic alterations in circulating cell-free DNA in virtue of autopsy analysis.
  Sci Rep 11(1):8398, 2021.
• Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Nakai S, Miyagi M, Kannon T, Tajima A, Tsuboi H, Konoshita T, Nakamura H. 
  Relationship between decreased mineral intake due to oral frailty and bone mineral density: Findings from Shika study.
  Nutrients 13(4):1193, 2021.
• Narukawa N, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Pham KO, Suzuki F, Asai A, Amatsu T, Kasahara T, Miyagi M, Nakamura M, Yamada Y, Nakamura H, Hayashi K, Hamagishi T, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H. 
  Relationship between vitamin intake and health-related quality of life in a Japanese population: A cross-sectional analysis of the Shika study.
  Nutrients 13(3):1023, 2021.
• Suzuki F, Morita E, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kannon T, Tajima A, Matsumoto S, Ishihara A, Hori D, Doki S, Oi Y, Sasahara S, Satoh M, Matsuzaki I, Yanagisawa M, Ikaga T, Nakamura H. 
  Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study.
  PLoS One 16(2):e0247926, 2021.
• Isobe Y, Asakura H, Tsujiguchi H, Kannon T, Takayama H, Takeshita Y, Ishii K, Kanamori T, Hara A, Yamashita T, Tajima A, Kaneko S, Nakamura H, Takamura T. 
  Alcohol intake is associated with elevated serum levels of selenium and selenoprotein P in humans.
  Front Nutr 8:633703, 2021.
• Hara A, Tsujiguchi H, Suzuki K, Suzuki F, Kasahara T, Oanh PK, Miyagi S, Kannon T, Tajima A, Wada T, Nakamura H. 
  Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese.
  J Nutr Sci 10:e2, 2021.
• Nakakura S, Hosomichi K, Uchino S, Murakami A, Oka A, Inoue I, Nakaoka H. 
  HLA-B*39:01:01 is a novel risk factor for antithyroid drug-induced agranulocytosis in Japanese population.
  Pharmacogenomics J 21(1):94-101, 2021.

欧文報告

• Imaki S, Iizuka K, Horikawa Y, Yasuda M, Kubota S, Kato T, Liu Y, Takao K, Mizuno M, Hirota T, Suwa T, Hosomichi K, Tajima A, Fujiwara Y, Yamazaki Y, Kuwata H, Seino Y, Yabe D. 
  A novel RFX6 heterozygous mutation (p.R652X) in maturity-onset diabetes mellitus: A case report.
  J Diabetes Investig 12(10):1914-1918, 2021.
• Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S. 
  HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.
  Blood 137(25):3576-3580, 2021.

2020年

欧文原著

• Li Y, Que L, Fukano K, Koura M, Kitamura K, Zheng X, Kato T, Aly HH, Watashi K, Tsukuda S, Aizaki H, Watanabe N, Sato Y, Suzuki T, Suzuki HI, Hosomichi K, Kurachi M, Wakae K, Muramatsu M. 
  MCPIP1 reduces HBV-RNA by targeting its epsilon structure.
  Sci Rep 10(1):20763, 2020.
• Suzuki K, Tsujiguchi H, Miyagi S, Thi Thu Nguyen T, Hara A, Nakamura H, Shimizu Y, Hayashi K, Yamada Y, Minh Nguyen P, Tao Y, Kannon T, Tajima A, Nakamura H. 
  Association between serum 25-hydroxyvitamin D concentrations and chronic pain: effects of drinking habits.
  J Pain Res 13:2987-2996, 2020.
• Hara A, Tsujiguchi H, Suzuki K, Tao Y, Nakamura H, Kasahara T, Nguyen TTT, Miyagi S, Shimizu Y, Kannon T, Tajima A, Wada T, Takamura T, Nakamura H. 
  Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects: the Shika study.
  Biomarkers 25(7):587-593, 2020.
• Gakuhari T, Nakagome S, Rasmussen S, Allentoft ME, Sato T, Korneliussen T, Chuinneagain BN, Matsumae H, Koganebuchi K, Schmidt R, Mizushima S, Kondo O, Shigehara N, Yoneda M, Kimura R, Ishida H, Masuyama T, Yamada Y, Tajima A, Shibata H, Toyoda A, Tsurumoto T, Wakebe T, Shitara H, Hanihara T, Willerslev E, Sikora M, Oota H. 
  Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations.
  Commun Biol 3(1):437, 2020.
• Oka A, Takagi A, Komiyama E, Yoshihara N, Mano S, Hosomichi K, Suzuki S, Haida Y, Motosugi N, Hatanaka T, Kimura M, Ueda MT, Nakagawa S, Miura H, Ohtsuka M, Tanaka M, Komiyama T, Otomo A, Hadano S, Mabuchi T, Beck S, Inoko H, Ikeda S. 
  Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.
  EBioMedicine 57:102810, 2020.
• Sato Y, Tajima A, Kiguchi M, Kogusuri S, Fujii A, Sato T, Nozawa S, Yoshiike M, Mieno M, Kojo K, Uchida M, Tsuchiya H, Yamasaki K, Imoto I, Iwamoto T. 
  Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.
  J Hum Genet 65(8):683-691, 2020.
• Sakai K, Kuwana M, Tanaka H, Hosomichi K, Hasegawa A, Uyama H, Nishio K, Omae T, Hishizawa M, Matsui M, Iwato K, Okamoto A, Okuhiro K, Yamashita Y, Itoh M, Kumekawa H, Takezako N, Kawano N, Matsukawa T, Sano H, Oshiro K, Hayashi K, Ueda Y, Mushino T, Ogawa Y, Yamada Y, Murata M, Matsumoto M. 
  HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR.
  Blood 135(26):2413-2419, 2020.
• Tada H, Hori M, Nomura A, Hosomichi K, Nohara A, Kawashiri MA, Harada-Shiba M. 
  A catalog of the pathogenic mutations of LDL receptor gene in Japanese familial hypercholesterolemia.
  J Clin Lipidol 14(3):346-351.e9, 2020.
• Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H; Japan Gout Genomics Consortium (Japan Gout). 
  Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.
  Ann Rheum Dis 79(5):657-665, 2020.
• Yahara H, Horita S, Yanamoto S, Kitagawa Y, Asaka T, Yoda T, Morita K, Michi Y, Takechi M, Shimasue H, Maruoka Y, Kondo E, Kusukawa J, Tsujiguchi H, Sato T, Kannon T, Nakamura H, Tajima A, Hosomichi K, Yahara K. 
  A targeted genetic association study of the rare type of osteomyelitis.
  J Dent Res 99(3):271-276, 2020.
• Matsumoto M, Tsuneyama K, Morimoto J, Hosomichi K, Matsumoto M, Nishijima H. 
  Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanism.
  Int Immunol 32(2):117-131, 2020.

欧文報告

• Romero VI, Pozo JC, Saenz S, Llamos-Paneque A, Liehr T, Hosomichi K, Tajima A. 
  A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14).
  Hum Genome Var 7:28, 2020.
• Kuwabara-Ohmura Y, Iizuka K, Liu Y, Takao K, Nonomura K, Kato T, Mizuno M, Hosomichi K, Tajima A, Miyazaki T, Horikawa Y, Yabe D. 
  A case of MODY5-like manifestations without mutations or deletions in coding and minimal promoter regions of the HNF1B gene.
  Endocr J 67(9):981-988, 2020.
• Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H. 
  Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels.
  Ann Rheum Dis 79(1):164-166, 2020.

2019年

欧文原著

• Hosoda Y, Miyake M, Schellevis RL, Boon CJF, Hoyng CB, Miki A, Meguro A, Sakurada Y, Yoneyama S, Takasago Y, Hata M, Muraoka Y, Nakanishi H, Oishi A, Ooto S, Tamura H, Uji A, Miyata M, Takahashi A, Ueda-Arakawa N, Tajima A, Sato T, Mizuki N, Shiragami C, Iida T, Khor CC, Wong TY, Yamada R, Honda S, de Jong EK, Hollander AID, Matsuda F, Yamashiro K, Tsujikawa A. 
  Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy.
  Commun Biol 2(1):468, 2019.
• Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, Yasutomo K. 
  A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.
  J Exp Med 216(12):2724-2735, 2019.
• Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H. 
  Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.
  Ann Rheum Dis 78(10):1430-1437, 2019.
• Kanzawa-Kiriyama H, Jinam TA, Kawai Y, Sato T, Hosomichi K, Tajima A, Adachi N, Matsumura H, Kryukov K, Saitou N, Shinoda K. 
  Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan.
  Anthropol Sci 127(2):83-108, 2019.
• Ogawa K, Okuno T, Hosomichi K, Hosokawa A, Hirata J, Suzuki K, Sakaue S, Kinoshita M, Asano Y, Miyamoto K, Inoue I, Kusunoki S, Okada Y, Mochizuki H. 
  Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese.
  J Neuroinflammation 16(1):162, 2019.
• Aoyama KI, Kimura M, Yamazaki H, Uchibori M, Kojima R, Osawa Y, Hosomichi K, Ota Y, Tanaka M, Yamada S, Nishimura G. 
  New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report.
  BMC Med Genet 20(1):126, 2019.
• Kasuga Y, Miyakoshi K, Tajima A, Saisho Y, Ikenoue S, Ochiai D, Matsumoto T, Arata N, Hata K, Tanaka M.
  Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus.
  J Diabetes Investig 10(3):817-826, 2019.
• Hirata J, Hosomichi K, Sakaue S, Kanai M, Nakaoka H, Ishigaki K, Suzuki K, Akiyama M, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Hirata M, Matsuda K, Momozawa Y, Inoue I, Kubo M, Kamatani Y, Okada Y.
  Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population.
  Nat Genet 51(3):470-480, 2019.
• Yamaguchi T, Hosomichi K, Takahashi M, Haga S, Nakawaki T, Hikita Y, Maki K, Tajima A.
  Orthognathic surgery induces genomewide changes longitudinally in DNA methylation in saliva.
  Oral Dis 25(2):508-514, 2019.

欧文報告

• Elbadry MI, Mizumaki H, Hosokawa K, Espinoza JL, Nakagawa N, Chonabayashi K, Yoshida Y, Katagiri T, Hosomichi K, Zaimoku Y, Imi T, Nguyen MAT, Fujii Y, Tajima A, Ogawa S, Takenaka K, Akashi K, Nakao S.
  Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.
  Haematologica 104(10):e447-e450, 2019.

2018年

欧文原著

• Romero V, Nakaoka H, Hosomichi K, Inoue I.
  High order formation and evolution of hornerin in primates.
  Genome Biol Evol 10(12):3167-3175, 2018.
• Tada H, Kawashiri MA, Nomura A, Teramoto R, Hosomichi K, Nohara A, Inazu A, Mabuchi H, Tajima A, Yamagishi M.
  Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease.
  J Clin Lipidol 12(6):1436-1444, 2018.
• Miki A, Sakurada Y, Tanaka K, Semba K, Mitamura Y, Yuzawa M, Tajima A, Nakatochi M, Yamamoto K, Matsuo K, Imoto I, Honda S.
  Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population.
  Invest Ophthalmol Vis Sci 59(13):5542-5547, 2018.
• Morimoto J, Nishikawa Y, Kakimoto T, Furutani K, Kihara N, Matsumoto M, Tsuneyama K, Kozono Y, Kozono H, Hozumi K, Hosomichi K, Nishijima H, Matsumoto M.
  Aire controls in trans the production of medullary thymic epithelial cells expressing Ly-6C/Ly-6G.
  J Immunol 201(11):3244-3257, 2018.
• Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Maki K, Marazita ML, Weinberg SM, Tajima A.
  Whole‐genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes.
  Oral Dis 24(7):1303-1309, 2018.
• Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Marazita ML, Weinberg SM, Maki K, Tajima A.
  Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology.
  Arch Oral Biol 96:33-38, 2018.
• Koganebuchi K, Gakuhari T, Takeshima H, Sato K, Fujii K, Kumabe T, Kasagi S, Sato T, Tajima A, Shibata H, Ogawa M, Oota H.
  A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes.
  PLoS One 13(7):e0200170, 2018.
• McColl H, Racimo F, Vinner L, Demeter F, Gakuhari T, Moreno-Mayar JV, van Driem G, Gram Wilken U, Seguin-Orlando A, de la Fuente Castro C, Wasef S, Shoocongdej R, Souksavatdy V, Sayavongkhamdy T, Saidin MM, Allentoft ME, Sato T, Malaspinas AS, Aghakhanian FA, Korneliussen T, Prohaska A, Margaryan A, de Barros Damgaard P, Kaewsutthi S, Lertrit P, Nguyen TMH, Hung HC, Minh Tran T, Nghia Truong H, Nguyen GH, Shahidan S, Wiradnyana K, Matsumae H, Shigehara N, Yoneda M, Ishida H, Masuyama T, Yamada Y, Tajima A, Shibata H, Toyoda A, Hanihara T, Nakagome S, Deviese T, Bacon AM, Duringer P, Ponche JL, Shackelford L, Patole-Edoumba E, Nguyen AT, Bellina-Pryce B, Galipaud JC, Kinaston R, Buckley H, Pottier C, Rasmussen S, Higham T, Foley RA, Lahr MM, Orlando L, Sikora M, Phipps ME, Oota H, Higham C, Lambert DM, Willerslev E.
  The prehistoric peopling of Southeast Asia.
  Science 361(6397):88-92, 2018.
  [PERSPECTIVES] Science 361(6397):31-32, 2018.
• Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M.
  Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation.
  Sci Rep 8(1):9745, 2018.
• Horikawa Y, Hosomichi K, Enya M, Ishiura H, Suzuki Y, Tsuji S, Sugano S, Inoue I, Takeda J.
  No novel, high penetrant gene might remain to be found in Japanese patients with unknown MODY.
  J Hum Genet 63(7):821-829, 2018.
• Sato Y, Tajima A, Sato T, Nozawa S, Yoshiike M, Imoto I, Yamauchi A, Iwamoto T.
  Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men.
  J Med Genet 55(6):415-421, 2018.
• Nishiyama A, Yamada T, Kita K, Wang R, Arai S, Fukuda K, Tanimoto A, Takeuchi S, Tange S, Tajima A, Furuya N, Kinoshita T, Yano S.
  Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model.
  Clin Cancer Res 24(10):2357-2369, 2018.
  [Highlights of This Issue] Clin Cancer Res 24(10):2235-2235, 2018.
• Imi T, Katagiri T, Hosomichi K, Zaimoku Y, Hoang Nguyen V, Nakagawa N, Tajima A, Yoshizato T, Ogawa S, Nakao S.
  Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia.
  Blood Adv 2(9):1000-1012, 2018.
• Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe SY, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T.
  Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.
  J Psychiatry Neurosci 43(3):194-200, 2018.
• Inoshita M, Umehara H, Watanabe SY, Nakataki M, Kinoshita M, Tomioka Y, Tajima A, Numata S, Ohmori T.
  Elevated peripheral blood glutamate levels in major depressive disorder.
  Neuropsychiatr Dis Treat 4:945-953, 2018.
• Sato Y, Hasegawa C, Tajima A, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Yamauchi A, Iwamoto T.
  Association of TUSC1 and DPF3 gene polymorphisms with male infertility.
  J Assist Reprod Genet 35(2):257-263, 2018.
• Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M.
  Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).
  J Autoimmun 86:75-92, 2018.
• Maruyama K, Aotsuka N, Kumano Y, Sato N, Kawashima N, Onda Y, Maruyama H, Katagiri T, Zaimoku Y, Nakagawa N, Hosomichi K, Ogawa S, Nakao S.
  Immune-mediated hematopoietic failure after allogeneic hematopoietic stem cell transplantation: a common cause of late graft failure in patients with complete donor chimerism.
  Biol Blood Marrow Transplant 24(1):43-49, 2018.

欧文報告

• Kayahashi K, Mizumoto Y, Myojo S, Mitani Y, Tajima A, Fujiwara H.
  A successful case of neoadjuvant chemotherapy and radical hysterectomy during pregnancy for advanced uterine cervical cancer accompanied by neonatal erythroderma.
  J Obstet Gynaecol Res 44(10):2003-2007, 2018.
• Koba H, Kimura H, Nishikawa S, Sone T, Abo M, Hara J, Hosomichi K, Tajima A, Kasahara K.
  Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations.
  Lung Cancer 122:146-150, 2018.

2017年

欧文原著

• Kita K, Arai S, Nishiyama A, Taniguchi H, Fukuda K, Wang R, Yamada T, Takeuchi S, Tange S, Tajima A, Nakada M, Yasumoto K, Motoo Y, Murakami T, Yano S.
  In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.
  Cancer Med 6(12):2972?2983, 2017.
• Watanabe H, Goto S, Mori H, Higashi K, Hosomichi K, Aizawa N, Takahashi N, Tsuchida M, Suzuki Y, Yamada T, Horii A, Inoue I, Kurokawa K, Narita I.
  Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy.
  Nephrol Dial Transplant 32(12):2072?2079, 2017.
• Kawano T, Hosomichi K, Inoue I, Shimono R, Onishi S, Nakame K, Kaji T, Matsufuji H, Ieiri S.
  Identification of a novel variant of the RET proto-oncogene in a novel family with Hirschsprung’s disease.
  Pediatr Surg Int 33(10):1041?1046, 2017.
• Kohmoto T, Masuda K, Naruto T, Tange S, Shoda K, Hamada J, Saito M, Ichikawa D, Tajima A, Otsuji E, Imoto I.
  Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer.
  J Med Invest 64(3.4):233-240, 2017.
• Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A.
  Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.
  Sci Rep 7(1):11442, 2017.
• Shinmyo Y, Terashita Y, Dinh Duong TA, Horiike T, Kawasumi M, Hosomichi K, Tajima A, Kawasaki H.
  Folding of the cerebral cortex requires Cdk5 in upper-layer neurons in gyrencephalic mammals.
  Cell Rep 20(9):2131-2143, 2017.
• Higashino T, Takada T, Nakaoka H, Toyoda Y, Stiburkova B, Miyata H, Ikebuchi Y, Nakashima H, Shimizu S, Kawaguchi M, Sakiyama M, Nakayama A, Akashi A, Tanahashi Y, Kawamura Y, Nakamura T, Wakai K, Okada R, Yamamoto K, Hosomichi K, Hosoya T, Ichida K, Ooyama H, Suzuki H, Inoue I, Merriman TR, Shinomiya N, Matsuo H.
  Multiple common and rare variants of ABCG2 cause gout.
  RMD Open 3(2):e000464, 2017.
• Akatsuka H, Kuga S, Masuhara K, Davaadorj O, Okada C, Iida Y, Okada Y, Fukunishi N, Suzuki T, Hosomichi K, Ohtsuka M, Tanaka M, Inoue I, Kimura M, Sato T.
  AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway.
  Biochem Biophys Res Commun 491(4):1098-1104, 2017.
• Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H.
  RXRB is a MHC-encoded susceptibility gene associated with anti-topoisomerase I antibody-positive systemic sclerosis.
  J Invest Dermatol 137(9):1878-1886, 2017.
• Nishi A, Numata S, Tajima A, Zhu X, Ito K, Saito A, Kato Y, Kinoshita M, Shimodera S, Ono S, Ochi S, Imamura A, Kurotaki N, Ueno SI, Iwata N, Fukui K, Imoto I, Kamiya A, Ohmori T.
  De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.
  Sci Rep 7(1):2887, 2017.
• Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S.
  Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.
  Blood 129(21):2908-2916, 2017.
  [Inside Blood Commentary] Blood 129(21):2824-2826, 2017.
• Kasuga Y, Hata K, Tajima A, Ochiai D, Saisho Y, Matsumoto T, Arata N, Miyakoshi K, Tanaka M.
  Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study.
  Endocr J 64(4):463-475, 2017.
• Ahmadloo S, Nakaoka H, Hayano T, Hosomichi K, You H, Utsuno E, Sangai T, Nishimura M, Matsushita K, Hata A, Nomura F, Inoue I.
  Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2.
  J Hum Genet 62(5):561-567, 2017.
• Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A.
  Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis.
  J Neurochem 141(1):124-136, 2017.
• Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.
  An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies.
  Hum Reprod Open 2017(1):hox002, 2017.
  [Correction] Hum Reprod Open 2017(1):hox005, 2017.
• Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.
  Effect of clozapine on DNA methylation in peripheral leukocytes from patients with treatment-resistant schizophrenia.
  Int J Mol Sci 18(3):632, 2017.
• Yamaguchi T, Hosomichi K, Yano K, Kim YI, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I.
  Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing.
  Hum Genome Var 4:17005, 2017.
• Kanzawa-Kiriyama H, Kryukov K, Jinam TA, Hosomichi K, Saso A, Suwa G, Ueda S, Yoneda M, Tajima A, Shinoda KI, Inoue I, Saitou N.
  A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan.
  J Hum Genet 62(2):213-221, 2017.
• Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S.
  Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel.
  Clin Exp Nephrol 21(1):63-75, 2017.
• Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A.
  Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals.
  Hum Genome Var 4:16044, 2017.
• Romero V, Hosomichi K, Nakaoka H, Shibata H, Inoue I.
  Structure and evolution of the filaggrin gene repeated region in primates.
  BMC Evol Biol 17(1):10, 2017.

2016年

欧文原著

• Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, Umehara H, Watanabe SY, Imoto I, Ohmori T.
  Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk.
  Psychiatry Res 246:833-837, 2016.
• Sato Y, Tajima A, Katsurayama M, Nozawa S, Miki Y, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.
  A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men.
  J Hum Genet 61(11):911-915, 2016.
• Hayano T, Matsui H, Nakaoka H, Ohtake N, Hosomichi K, Suzuki K, Inoue I.
  Germline variants of prostate cancer in Japanese families.
  PLoS One 11(10):e0164233, 2016.
• Okamoto Y, Ishida H, Kimura R, Sato T, Tsuchiya N, Murayama S, Fukase H, Nagaoka T, Adachi N, Yoneda M, Weber A, Kato H.
  An Okhotsk adult female human skeleton (11th/12th century AD) with possible SAPHO syndrome from Hamanaka 2 site, Rebun Island, northern Japan.
  Anthropol Sci 124(2):107-115, 2016.
• Umehara H, Numata S, Tajima A, Nishi A, Nakataki M, Imoto I, Sumitani S, Ohmori T.
  Calcium signaling pathway is associated with the long-term clinical response to selective serotonin reuptake inhibitors (SSRI) and SSRI with antipsychotics in patients with obsessive-compulsive disorder.
  PLoS One 11(6):e0157232, 2016.
• Kawarai T, Tajima A, Kuroda Y, Saji N, Orlacchio A, Terasawa H, Shimizu H, Kita Y, Izumi Y, Mitsui T, Imoto I, Kaji R.
  A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability.
  J Neurol Neurosurg Psychiatry 87(6):656-662, 2016.
• Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama S, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T.
  A significant causal association between C-reactive protein levels and schizophrenia.
  Sci Rep 6:26105, 2016.
  [Retraction] Sci Rep 8:46947, 2018.
• Nakaoka H, Gurumurthy A, Hayano T, Ahmadloo S, Omer WH, Yoshihara K, Yamamoto A, Kurose K, Enomoto T, Akira S, Hosomichi K, Inoue I.
  Allelic imbalance in regulation of ANRIL through chromatin interaction at 9p21 endometriosis risk locus.
  PLoS Genet 12(4):e1005893, 2016.
• Yamauchi T, Kimura R, Kawaguchi A, Sato T, Yamaguchi K, Toma T, Miyamoto K, Fukase H, Yamaguchi T, Ishida H.
  A comparative study of craniofacial measurements between Ryukyuan and mainland Japanese females using lateral cephalometric images.
  Anthropol Sci 124(1):45?62, 2016.
• Shinmyo Y, Tanaka S, Tsunoda S, Hosomichi K, Tajima A, Kawasaki H.
  CRISPR/Cas9-mediated gene knockout in the mouse brain using in uteroelectroporation.
  Sci Rep 6:20611, 2016.
• Polat M, Takeshima SN, Hosomichi K, Kim J, Miyasaka T, Yamada K, Arainga M, Murakami T, Matsumoto Y, de la Barra Diaz V, Panei CJ, Gonzalez ET, Kanemaki M, Onuma M, Giovambattista G.
  A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis.
  Retrovirology 13(1):4, 2016.

欧文報告

• Tada H, Hosomichi K, Okada H, Kawashiri M, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K.
  A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing.
  Clin Chim Acta 453:194?196, 2016.
• Okudaira Y, Hosomichi K, Ozaki Y, Shiina T, Mitsunaga S.
  Correction of the HLA-DQB1*04:01:01 sequence at position 79 in exon 1.
  HLA 87(1):57?58, 2016.

2015年

欧文原著

• Savage PE, Matsumae H, Oota H, Stoneking M, Currie TE, Tajima A, Gillan M, Brown S.
  How ‘circumpolar’ is Ainu music? Musical and genetic perspectives on the history of the Japanese archipelago.
  Ethnomusicology Forum 24(3):443-467, 2015.
• Hayano T, Yamada S, Hosomichi K, Nakaoka H, Yoshihara K, Adachi S, Kashima K, Tanaka K, Enomoto T, Inoue I.
  Identification of novel exonic mobile element insertions in epithelial ovarian cancers.
  Hum Genome Var 2:15030, 2015.
• Umehara H, Numata S, Tajima A, Kinoshita M, Nakaaki S, Imoto I, Sumitani S, Ohmori T.
  No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.
  Hum Psychopharmacol Clin Exp 30(5):372-376, 2015.
• Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Oka A, Shiina T, Inoko H, Inoue I.
  Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients.
  J Hum Genet 60(8):449-454, 2015.
• Numata S, Kinoshita M, Tajima A, Nishi A, Imoto I, Ohmori T.
  Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis.
  BMC Med Genet 16(1):54, 2015.
• Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, Hashimoto R, Imoto I, Ohmori T.
  Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions.
  Biol Sex Differ 6:11, 2015.
• Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.
  An association study of four candidate loci for human male fertility traits with male infertility.
  Hum Reprod 30(6):1510-1514, 2015.
• Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.
  Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study.
  Hum Reprod 30(6):1505-1509, 2015.
• Nakagome S, Sato T, Ishida H, Hanihara T, Yamaguchi T, Kimura R, Mano S, Oota H; The Asian DNA Repository Consortium [Tajima A is a member].
  Model-based verification of hypotheses on the origin of modern Japanese revisited by Bayesian inference based on genome-wide SNP data.
  Mol Biol Evol 32(6):1533-1543, 2015.
• Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H.
  Silver nanoscale hexagonal column chips for detecting cell-free DNA and circulating nucleosomes in cancer patients.
  Sci Rep 5:10455, 2015.
• Numata S, Ishii K, Tajima A, Iga JI, Kinoshita M, Watanabe S, Umehara H, Fuchikami M, Okada S, Boku S, Hishimoto A, Shimodera S, Imoto I, Morinobu S, Ohmori T.
  Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation.
  Epigenetics 10(2):135-141, 2015.

欧文総説

• Hosomichi K, Shiina T, Tajima A, Inoue I.
  The impact of next-generation sequencing technologies on HLA research.
  J Hum Genet 60(11):665-673, 2015.

2014年

欧文原著

• Yonezawa T, Kurata R, Tajima A, Cui X, Maruta H, Nakaoka H, Nakajima K, Inoko H.
  Comparative proteomics and network analysis identify PKC epsilon underlying long-chain fatty acid signaling.
  J Proteomics Bioinform 7(11):340-346, 2014.
• Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Takeda M, Ohmori T.
  Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions.
  Neuromolecular Med 16(4):697-703, 2014.
• Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T.
  Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.
  Schizophr Bull 40(5):1154-1163, 2014.
• Nakaoka H, Tajima A, Yoneyama T, Hosomichi K, Kasuya H, Mizutani T, Inoue I.
  Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm.
  Stroke 45(8):2239-2245, 2014.
• Yu W, Zheng H, Lin W, Tajima A, Zhang Y, Zhang X, Zhang H, Wu J, Han D, Rahman NA, Korach KS, Gao GF, Inoue I, Li X.
  Estrogen promotes Leydig cell engulfment by macrophages in male infertility.
  J Clin Invest 124(6):2709-2721, 2014.

欧文総説

• Utsunomiya T, Shimada M, Morine Y, Tajima A, Imoto I.
  Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis.
  Cancer Sci 105(7):749-754, 2014.